Migraine headaches are very common, affecting 12% of the worldwide population. Migraine headaches usually start in response to a specific trigger. Typically there is mild pain that escalates to severe pain, characterized by throbbing or pulsing headache, often affecting one side of the head. Associated symptoms include nausea, vomiting and sensitivity to light and/or sound. Migraine sufferers may feel sensory warning symptoms, called an aura, before onset of the headaches. Migraines seem to run in families. The mainstay of treatment solutions are a group of drugs called “triptans” which work by blocking the release of pro inflammatory compounds in the brain. They are fairly effective for aborting or lessening harshness of migraine headaches. Unfortunately, side effects could be significant and may include rebound headaches, pain or chest tightness, dizziness, nausea, vomiting, or warmth, redness, or tingling beneath the skin. Triptans are also costly, and many insurance providers restrict the amount of these medications that may be dispensed to patients. Another group of medicines called ergot alkaloids can also be prescribed for migraines, however are less efficient than triptans.
Unfortunately, little research exists that proves the mechanism through which cannabinoids alleviate migraines, inspite of the overwhelming anecdotal reports from patients suffering with them. Recent studies demonstrate that migraine headaches might be due to endocannabinoid deficiency and abnormal inflammatory response. Remember that the endocannabinoid system exists to keep up cellular homeostasis. Often migraine sufferers report that headaches begin in reaction to your trigger, such as bright light, hunger, hormones, or certain smells or foods. The trigger event causes an imbalance inside the brain, that ought to then trigger the creation of endocannabinoids to keep up homeostasis. If an individual is deficient in endocannabinoids, the imbalance continues, leading to progression of the migraine headache. The trigger might also cause inflammation, which might become out of control and play a role in the resulting pain.
The few studies who have checked out the link between migraines and also the ECS are summarized here:
Endocannabinoids and synthetic cannabinoids inhibited receptors that control vomiting and pain, working to block these symptoms. THC reduces serotonin release (which blocks vomiting and pain) from the platelets of human migraine sufferers.
Cannabinoids were found to bind to regions of the periaqueductal gray matter (an part of the brain that modulates pain transmission) which were implicated in migraine generation.Three cases were reported of chronic heavy users of cannabis developing severe migraine attacks after abrupt cessation of usage; authors suggested that these particular rebound attacks are exactly like similar rebound headaches experienced by migraine patients whenever they abruptly stop other migraine treatment. Genes that allow for increased inflammation were seen in migraine patients and never present in control subjects.
Endocannabinoid levels were decreased in patients with chronic migraine and medication-over-use headaches suggesting that endocannabinoid dysfunction is associated with these two chronic conditions
Cannabis has been used for centuries to take care of headaches. Medical cannabis patients have found relief of pain, less nausea, and better sleep. Patients also report less frequency and fewer seriousness of their migraine headaches with medical cannabis use. A number of well-known trigger factors for migraine headaches, specifically sleep deprivation and anxiety or stress, are alleviated with cannabis, thereby reducing the quantity of migraine attacks. Patients also are convinced that they spend less healthcare dollars on expensive migraine medications, have less missed days in class or at the job, and also have overall improved total well being.
There is no question that THC-rich cannabis may help abort or lessen the seriousness of a migraine, particularly when taken in the start of the pain. Some patients report that low-dose, regular usage of THC-rich medicine significantly reduces frequency and severity of the headaches. Other patients report that daily CBD-rich cannabis prevents migraine from occurring. After the headache begins, a rapid delivery method like inhalation or sublingual tincture is preferred by most. Specific strain choice is a result of trial and error for most patients.
Most cannabinoids are classified under schedule 1 in the Federal Controlled Substances Act 1970, in addition to heroin and ecstacy. So they can not be prescribed by physicians, and by implication, do not have accepted medical use having a high abuse potential. Despite their legal status, hallucinogens and cannabinoids are utilized by patients for relief of headache, helped through the growing quantity of American states that have legalized medical marijuana. Cannabinoids particularly have a long background of use in the abortive cuudpe and prophylactic treatment of migraine before prohibition and therefore are still utilized by patients being a migraine abortive particularly. Most practitioners are unacquainted with the prominence cannabis or “marijuana” once held in medical practice. Hallucinogens are increasingly used by cluster headache patients outside of physician recommendation mainly to abort a cluster period and sustain quiescence in which there exists considerable anecdotal success. The legal status of cannabinoids and hallucinogens has for a long time severely inhibited scientific research, and you may still find no blinded studies on headache subjects, that we might assess true efficacy.